Provigil is also sold under the brand name Modalert. It is available in many countries outside of the continent. In general, Provigil works for the majority of people, but some may notice a reduction in effectiveness after a few weeks of treatment. To find out whether Modalert works for you, talk with your doctor about your current dosage and any possible side effects. You may need a higher dosage or switch to another medication altogether.
Modalert increases stress levels by modulating the hypothalamic-pituitary-adrenal (HPA) axis.
The HPA axis is responsible for regulating the body’s response to stress, which involves the release of hormones. An appropriate response to stress involves a rapid increase and subsequent fall in cortisol levels. The HPA axis is an important part of the stress response and dysfunction can cause many physical problems. This disorder is cause by a variety of factors, including genetics and the environment we live in today.
Aberrant stress responses result in neuroimmune dysfunction and fatigue. MDD is associate with higher levels of pro-inflammatory cytokines, which are link to fatigue syndromes. These proteins may increase the activity of neuronal 5-HT transporters and reduce 5-HT availability in synapses. Additionally, changes in the activity of DA may contribute to the subjective experience of fatigue.
Modalert increases energy levels by modulating the hypothalamic-pituitary-adrenal (HPA) axis.
The human body responds to chronic stressors by producing a series of hormones, which regulate the entire body’s functions. Among these are the adrenal glands and the pituitary gland. Activation of the HPA axis causes changes in hormone levels and other physiological processes.
Researchers have found that chronic exposure to proinflammatory cytokines lowers serotonin levels. This may account for the U-shaped relationship between serotonin and fatigue. Although studies suggest a positive relationship between low serotonin levels and cancer-related fatigue, no research has proven that these drugs improve fatigue.
A major benefit of Modalert is its ability to improve energy levels. Modalert 200 supplements increase energy levels by modulating the hypothalamic-pituitary-adrenal (HPA) axis. Since this wakefulness-promoting drug is already approve for the treatment of narcolepsy, research is being done to determine its potential social. The HPA axis has multiple physiological and behavioral effects, including increased wakefulness and sleep deprivation.